Circulating testosterone levels peak 10 to 12 hours after initial administration and reach a stable state within 24 hours (1). The testosterone levels of men who receive testosterone injections peak 2 to 3 days after receiving the injections). From that point on, testosterone levels gradually decrease until it's time for another testosterone injection. A meta-analysis looked at studies on testosterone replacement therapy that spanned a 35-year period.
They concluded that libido, sexual satisfaction, improved erections and increased frequency of erection can occur after three weeks to 30 days. This and the fact that cypionate requires the least amount of time and effort to maintain adequate testosterone levels make it the most popular testosterone treatment option. Prostate-specific antigen and volume increase and stabilize after 12 months; the additional increase should be related to aging and not to testosterone replacement therapy. At its most basic level, the time needed to see the effects of testosterone replacement therapy depends on the type and dose of medication you are taking.
A better route may be to take testosterone injections in smaller doses twice a week, which may allow for more stable levels of testosterone. The interesting thing is that increasing the transdermal dose will not necessarily increase serum testosterone, since it seems that this route reduces returns. And while the full effects of testosterone treatment may take several months to fully realize, there are some short-term benefits that make the wait worth the wait. Hormone replacement therapy (HRT) or a bioidentical hormone replacement therapy (BHRT) regimen will help restore testosterone levels to a healthy baseline level.
Control your estradiol level while you are taking testosterone, as high estrogen levels can limit the effectiveness of TRT. Sleeping well, eating well, and exercising will help improve the effectiveness of testosterone treatment. Both the pituitary gland and the penis gland stimulate testosterone production in the adrenal glands and testicles. Because each route of testosterone administration is different, there are also differences in how quickly these “types of testosterone” tend to work.
Therefore, after about a full year of receiving testosterone injections, the positive effects that result from the injections over that year are more likely to be maintained over the long term. The rest of the testosterone pills end up in the liver, where toxicity can build up and cause health problems. When the liver produces a large amount of enzymes to break down excess testosterone, it tells the brain. Testosterone replacement therapy is a safe and effective way to improve many symptoms associated with low testosterone levels, such as weight gain, fatigue, and decreased libido.